Yup, taking b-line from Eastgate would probably be the best. Takes about 30 mins to get to Mac from there, only downside being that b-line doesn't actually go inside the campus, but its only a couple mins walk to most buildings from Main St.
And to get back home, either take the bus from the hospital or the stop across the hospital. Last one leaves 7:00 pm I think (after that you have to rely on the 1/1A, which takes about the same time since less people on the bus at nighttime)